I have seen some recent research on fluctuating mesocyle rep ranges to maximize an hypertrophy response by hitting both muscle fibers and keeping from hitting plateaus and or injury from constantly training within the same rep ranges. For example meso 1&2 consist of 50% of 5-10 rep range and 25% from 10-20 and 20+ rep range and then just switching those ratios of bias towards rep ranges in each mesocycle. What are your thoughts on this approach vs. using one lower repper set and then a higher repper back off set? Many thanks!
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I believe Mike Israetel is a big proponent of this approach, and imo it makes sense, since hypertrophy is not confined to the 6-12 rep range. You may also find that certain body parts respond better to different rep ranges, and this way you can determine what those might be and proceed from there accordingly.